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Short-term symptomatic treatment of generalized anxiety disorder. Buy Alpragen 1 mg Xanax is indicated only when the disorders are severe, disrupt normal functioning or are very troublesome for the patient. As with all benzodiazepines, doctors must be aware that long-term use of the drug may lead to the development of drug dependence.
Benzodiazepine derivative. It exerts a dose-dependent inhibitory effect on o.u.n.n. stimulates and facilitates GABA inhibition. Buy Alpragen 1 mg Xanax has an anxiolytic effect, while maintaining the effect of reducing muscle tone, anticonvulsant and sedative and sleeping pills.
After oral administration, Buy Alpragen 1 mg Xanax is well absorbed from the gastrointestinal tract. The maximum serum concentration is reached after 1-2 hours. Alprazolam binds to 70-80% plasma proteins. It is metabolised primarily in the liver for α-hydroxyalrazole (it has at least half as strong as alprazolam) and inactive benzophenone derivative.
However, their plasma concentrations are small. Buy Alpragen 1 mg Xanax is mainly excreted in the urine in unchanged form and in the form of metabolites. Medium T0,5 in the serum is 10 to 12 h, but in the elderly the excretion is slower and the described range ranges from 6.3 to 26.9 h.
Hypersensitivity to the active substance, other benzodiazepines or to any of the excipients. Myasthenia gravis. Severe respiratory failure. Sleep apnea syndrome. Severe hepatic failure. acute poisoning with alcohol or other substances. Concomitant use of substances active on the CNS. Glaucoma with a narrow angle of perception.
During the use of Buy Alpragen 1 mg Xanax, tolerance and / or addiction may occur. The drug may cause amygdala, which symptoms usually occur a few hours after taking the drug – to reduce the risk should provide the patient with 7-8 hours of uninterrupted sleep. In the event of psychological and “paradoxical” reactions (such as restlessness, agitation, irritability, aggressiveness, delusions, fits of rage, nightmares, hallucinations, psychoses, inappropriate or unusual behavior), the drug should be discontinued. The probability of their occurrence is greater in the elderly.
Pregnancy and lactation:
The use of Buy Alpragen 1 mg Xanax during pregnancy can only be justified if the therapeutic indications and dosage are strictly adhered to. Based on data from cohort studies, alprazolam used in the first trimester of pregnancy may increase the risk of serious birth defects. Some early clinical control epidemiological studies have shown an increased risk of cleft lip and / or palate. Treatment with high doses of benzodiazepines, in II and / or III trimester, caused a decrease in fetal movements and fluctuations in the fetal heart rhythm. If Buy Alpragen 1 mg Xanax is used in the third trimester of pregnancy, the newborn baby may have a limp child syndrome, with symptoms such as: axial hypotension, problems with food sucking leading to small body weight gains in the newborn.
Very often: sedation, drowsiness. Common: decreased appetite, confusion, depression, ataxia, impaired coordination, impaired memory, speech disorder, concentration difficulties, headache and dizziness, light-headedness, constipation, nausea. Uncommon: hyperprolactinemia, hallucinations, anger, aggressive behavior, hostile behavior, anxiety, agitation, changes in libido, insomnia, thinking disorders, nervousness, agitation, amnesia, dystonia, tremor, dry mouth, hypotension, tachycardia, mucosal congestion nose, vomiting, diarrhea, increased salivation, jaundice, abnormal liver function, dermatitis, skin reactions, weakness in muscle strength, incontinence, urinary retention, sexual dysfunction, menstrual disorders, weakness, irritability, weight change, increased intraocular pressure.
Orally. Adults: the usual dose for generalized anxiety disorder is 0.25 mg to 0.5 mg 3 times a day. It can be increased (if necessary) at intervals of 3 to 4 days up to a maximum dose of 4 mg per day.Special groups of patients. In elderly patients, treatment should be started at a low initial dose of 0.25 mg 2 to 3 times a day. If tolerated well, the dose may be increased gradually but not more than 0.5 mg every 3 days. If adverse reactions occur, the dose should be reduced. In elderly patients in good physical condition, the maximum dose should be 1.5 mg per day. In the debilitated elderly patients, the maximum dose should be limited to 0.75 mg daily. In patients with debilitating diseases, cautious introduction of starting doses is also necessary and similar doses of maximal doses from 0.75 mg to 1.5 mg per day are recommended, depending on the degree of cachexia or organ failure.